2) There is a disease pandemic that affects all of us. Its onset is slow but progressive and it inevitably gets worse once it is established. Symptoms include skin damage and inelasticity, loss of muscle tone with consequent lethardy, neurological degradation, bone damage, and at a cytological level damage to chromosomes and errors in mitochondrial DNA transcription that appear to drastically increase susceptibility to cancer. In extreme cases, it kills, although victims frequently die of other causes first. It may well be an acquired zoonosis or an endogenous retrovirus, because it is more or less universal among mammals but members of some other classes of animal (such as reptiles and fish) don't show obvious signs of it. This disease is senescence, and it would make me very happy indeed if people stopped treating it as inevitable and started treating it as a pathological condition that needs curing. I am myself feeling the early onset signs (I'm in my forties) and having to watch the decay of elderly relatives, who I remember from their vigorous middle age, fills me with a sense of helpless anger. (In fact, I'm not sure abolishing senescence shouldn't be in the #1 place, ahead of world peace: at least we have a chance of avoiding war.)
3) I was originally going to put a cure for AIDS and Cancer in at this level — as a bumper-pack, I guess -- but I've changed my mind. AIDS and cancer make life a misery for many and kill up to a third of us, but there's some hope that they can be abolished without invoking a magic wand. On the other hand, as a species, we suffer from a dismaying surfeit of, to put it bluntly, misogynistic old sacerdotal bigots. It's not simply a matter of being a member of the clergy; I have no beef with belief itself (although I frequently consider it misplaced, irrational, or just plain silly). Rather, it is with the expression of bigoted religious beliefs that punish or restrict the freedom of others, within a political or cultural framework that provides them with the force or actuality of law. In Saudi Arabia, a woman who was gang raped was subsequently sentenced to be lashed for adultery (yes, I know she was subsequently pardoned; that's not the point); in Africa, lying clergy assert that condoms spread AIDS and preach against their use: in Nicaragua a church-inspired ban on abortion is killing women with ectopic pregnancies: children are witch hunted in Nigeria, homosexuals around the world are routinely preached against and persecuted, as are religious minorities, such as Baha'i in Iran ... the list is endless. It's mostly women who are on the receiving end of this -- the "minority" that's a majority, constituting about 51% of the human population -- but when you add all the other out-groups up, I'd be surprised if less than two-thirds of humanity aren't suffering direct or indirect privation as a result of religious bigotry. I just want those who preach intolerance and hatred to stop.
7) Global climate change is clearly a big deal. It doesn't matter whether it's anthropogenic or a consequence of natural variation in insolation -- it's going to affect us either way, and the cause only affects us insofar as it might determine some of the things we've got to do to survive it. Similarly, it's fairly clear that we are not, contrary to orthodox Green ideology, going to deal with this by wailing, putting on hair shirts, and going back to being pre-industrial peasant subsistence farmers. Nor are we going to deal with it by reducing our carbon budget. (You want to reduce our species' carbon budget? Get a rifle and shoot someone. You don't get a lower carbon budget than a corpse. NB: please don't suggest this to some of our more excitable politicians who might be worrying about meeting their carbon trading limits in the near future. That would be Bad.) No; dealing with global climate change is going to take big business and big engineering projects. Lots of nuclear reactors, solar power farms, and plants pumping CO2 into the salt domes of evacuated oil and gas fields. All of which means it's going to cost big money, but in turn, it's going to make big profits for the companies that wise up first and realize that mitigating climate change can be a shiny new business proposition. Please, let's stop thinking negative-sum about climate change and start thinking positive-sum? Capitalism will clean up its own shit -- once it acquires a new set of taste buds and realizes it's delicious.
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