The Null Device

When testing drugs for treating depression on lab mice, it is important to have ways of determining whether or not a mouse is depressed, or suffering from the mouse equivalent of depression. Not surprisingly, mice deemed to be depressed are the ones which give up and stop struggling when faced with difficulty, and which get little joy from life:

Forced swimming test. The rat or mouse is placed into a cylinder partially filled with water from which escape is difficult. The longer it swims, the more actively it is trying to escape; if it stops swimming, this cessation is interpreted as depressionlike behavior, a kind of animal fatalism.

Sugar water preference. The preference an animal shows for sugar water is taken as an indication of its ability to derive pleasure, a quality that is missing in depression. Most rodents, when given two identical-looking sources of water, will drink much more of the sweetened water than the plain water. Rodents exposed to chronic stress or whose brains have been manipulated show no such preference.

(via Boing Boing) ¶ depression despair mice mouse psychology science 0

Scientists have created a mouse that's permanently happy. The mouse lacks the TREK-1 gene, which affects the transmission serotonin in the brain, and as such doesn't suffer from depression (which, presumably, normal mice do):

Mice without the TREK-1 gene ('knock-out' mice) were created and bred in collaboration with Dr. Michel Lazdunski, co-author of the research, in his laboratory at the University of Nice, France. "These 'knock-out' mice were then tested using separate behavioral, electrophysiological and biochemical measures known to gauge 'depression' in animals," says Dr. Debonnel. "The results really surprised us; our 'knock-out' mice acted as if they had been treated with antidepressants for at least three weeks."

(via /.) ¶ biology genetics happiness mouse science 0

The next radical innovation from Apple is expected to be a two-button mouse. Mass confusion among Mac users expected.

"Jaws will drop," said one insider.

¶ apple mouse 1