In some ways, the posthumans running a simulation are like gods in relation to the people inhabiting the simulation: the posthumans created the world we see; they are "omnipotent" in the sense that they can interfere in the workings of our world even in ways that violate its physical laws; they are "omniscient" in the sense that they can see everything that happens. However, all the demigods except those at the fundamental level of reality are subject to sanctions imposed upon them by the more powerful gods living at deeper levels.
(So there is a God and ve is a simulation hacker? Not exactly a reassuring theogony that we're living in what may be a computer toy. "As flies to wanton boys we are to the Gods".)
We can, however, conclude that one naïve transhumanist dogma is false: The probability that you or your descendants will ever run an ancestor-simulation is negligible, unless you are now living in such a simulation.